DEPRESI

AFRISUSNAWATI RAUF
POKOK BAHASAN
1 EPIDEMIOLOGI

2 ETIOLOGI

3 PATOFISIOLOGI

4 TATALAKSANA TERAPI

5 PERTIMBANGAN DALAM PEMILIHAN OBAT

6 EVALUASI HASIL TERAPI

 • Section Break
Suatu gangguan mood yang bersifat searah (unipolar), yaitu suatu
emosi yang meresap dan menetap berupa perasaan tertekan, yang
dalam kondisi ekstrim, sangat mempengaruhi persepsi seseorang
terhadap dunia
ETIOLOGI

KONDISI PENGGUNAAN
FAKTOR FAKTOR OBAT &
KEPRIBADIAN LINGKUNGAN MEDIK
GENETIK PENYALAH-
GUNAAN ZAT
PATOFISIOLOGI
KLASIFIKASI
BERDASARKAN KEPARAHAN
DEPRESI MAYOR/ BERAT
DEPRESI ATIPIKAL
DYSTHYMIA
DEPRESI PSIKOTIK

BERDASARKAN WAKTU
TERJADINYA
DEPRESI POST PARTUM
PREMENSTRUAL DYSPHORIC DISORDER
DEPRESI MUSIMAN
PATOFISIOLOGI
HIPOTESIS
HIPOTESIS AMIN BIOGENIK
Depresi disebabkan oleh kekurangan
dalam senyawa katekolamin, yaitu
Norepinefrin (NE), dan serotonin (5-HT)

HIPOTESIS PERMISIF
Berkurangnya 5-HT menyebabkan depresi
karena “mengijinkan” turunnya kadar NE

HIPOTESIS SENSITIVITAS RESEPTOR

Reseptor yang berada di saraf pasca sinaptik dapat
mengalami supersensitivitas. Supersensitivitas merupakan
respon yang merupakan kompensasi dari saraf pasca
sinaptik saat menerima stimulasi yang terlalu sedikit

ATROFI HIPPOCAMPUS
Terjadi penurunan volume hippocampus pada penderita depresi
akibat terjadinya kekambuhan episode depresi berat yang
berulang
 PATOFISIOLOGI
RASA TERTEKAN/ SEDIH HAMPIR SEPANJANG BERULANG KALI MEMIKIRKAN
HARI DAN TERJADI SETIAP HARI. KEMATIAN

PENURUNAN MINAT ATAU PENURUNAN KEMAMPUAN UNTUK

KESENANGAN YANG SIGNIFIKAN BERFIKIR ATAU BERKONSENTRASI
ATAU KETIDAKYAKINAN, HAMPIR
GEJALA SETIAP HARI

PENURUNAN BERAT BADAN YANG DAN PERASAAN TIDAK BERHARGA ATAU

SIGNIFIKAN WALAUPUN TIDAK
MELAKUKAN DIET
TANDA PERASAAN BERSALAH YANG
BERLEBIHAN ATAU TIDAK
SELAYAKNYA

INSOMNIA ATAU HIPERSOMIA KELETIHAN ATAU KEHABISAN

HAMPIR SETIAP HARI ENERGI HAMPIR SETIAP HARI

AGITASI PSIKOMOTOR ATAU

RETARDASI HAMPIR SETIAP HARI
 TATALAKSANA TERAPI

SASARAN TERAPI
PERUBAHAN BIOLOGIS/
EFEK BERUPA MOOD/ STRATEGI TERAPI
PERASAAN
MENGGUNAKAN TERAPI FARMAKOLOGI DAN
MODULASI 5-HT DAN NE NON FARMAKOLOGI YANG DAPAT
OTAK DENGAN AGEN-AGEN MEMODULASI KADAR 5-HT DAN NE DI OTAK
YANG SESUAI UNTUK
MENCAPAI
KESEIMBANGAN
TATALAKSANA TERAPI
TERAPI NON FARMAKOLOGI
TERAPI PERILAKU KOGNITIF
TERAPI INTERPERSONAL
TERAPI ELEKTROKONVULSIF

TERAPI FARMAKOLOGI
OBAT ANTIDEPRESAN
 ANTIDEPRESAN
BERDASARKAN MEKANISME AKSI

SELECTIVE SEROTONIN SEROTONIN NOREPINEPHRINE NOREPINEPHRINE AND DOPAMINE

REUPTAKE INHIBITOR REUPTAKE INHIBITORS REUPTAKE INHIBITORS (NDRIS)
(SNRIS)
(SSRI)
 ANTIDEPRESAN

TRYCYCLIC MONOAMIN OKSIDASE INHIBITOR SEROTONIN ANTAGONIST

ANTIDEPRESSANT (MAOI) AND REUPTAKE INHIBITOR
(SARIs) / ANTAGONIS 5-HT2
PERTIMBANGAN DALAM PEMILIHAN OBAT
KONTRAINDIKASI
01 Semua antidepresan adalah kontraindikasi
pada pasien dengan riwayat hipersensitif
terhadap komponen apapun

EFEK SAMPING
02 Profil efek samping utama beberapa obat
antidepresan dapat menjadi pertimbangan
dalam pemilihan obat
PEMILIHAN OBAT PADA POPULASI KHUSUS
03
PEDIATRIK
PASIEN GERIATRIK
PASIEN WANITA HAMIL/ MENYUSUI
PASIEN DEPRESI DENGAN GANGGUAN PSIKOTIK
EVALUASI HASIL TERAPI

Selama penggunaan antidepresan,

perlu dilakukan pemantauan hasil terapi
baik pada fase akut, fase lanjutan, dan
fase pemeliharaan

Parameter yang harus dipantau:

1. Hilangnya gejala depresi
2. Perbaikan fungsi sosial dan okupasional
3. Ada tidaknya keinginan dan ide bunuh diri
4. Efek-efek samping yang tidak diinginkan
Thank you
 The 2-page Quick Inventory of Depressive Symptomatology (16-item)
(Self-Report) (QIDS-SR16) is intended to be used with patients as part of a healthcare visit
and returned to a healthcare provider for scoring when completed.

FOR PROVIDER USE ONLY

Scoring Instructions for the Depression Questionnaire

Quick Inventory of Depressive Symptomatology (QIDS-SR16)

The QIDS-SR16 can be useful in identifying depressive symptom severity and changes in these symptoms over time.1

To score the QIDS-SR162:

1. Enter the highest score on any 1 of the 4 sleep items (items 1 to 4).
Enter the highest score on any 1 of the 4 weight items (items 6 to 9).
Enter the highest score on either of the 2 psychomotor items (15 and 16).
2. There will be one score for each of the 9 DSM-IV Major Depressive Disorder symptom domains.
3. Add the scores of the 9 items (sleep, weight, psychomotor changes, depressed mood,
decreased interest, fatigue, guilt, concentration, and suicidal ideation) to obtain the total score.

Total scores range from 0-27

Higher scores are associated with increased severity in depressive symptoms*

Normal/No Depression 0-5

Mild Depression 6-10 If you feel the patient is suicidal, take action to
Moderate Depression 11-15 assess the patient’s immediate safety and determine
Severe Depression 16-20 the most appropriate setting for treatment.3
Very Severe Depression 21-27

*These are general guidelines based on the University of Pittsburgh Epidemiology Data Center. IDS-QIDS,
2011. Clinical judgment should always be used to make a diagnosis of major depression and to make
decisions regarding the need for and type of treatment interventions.

References: 1. Rush AJ, Trivedi MH, Ibrahim HM, et al. The 16-item Quick Inventory of Depressive Symptomatology (QIDS), clinician rating (QIDS-C),
and self-report (QIDS-SR): a psychometric evaluation in patients with chronic major depression. Biol Psychiatry. 2003;54:573-583. 2. University of
Pittsburgh. Epidemiology Data Center. Inventory of depressive symptomatology (IDS) & quick inventory of depressive symptomatology (QIDS). IDS-QIDS,
2011. http://www.ids-qids.org/index2.html. Accessed January 8, 2014. 3. American Psychiatric Association. Practice guideline for the assessment and
treatment of patients with suicidal behaviors. Arlington, VA: American Psychiatric Association; 2010. http://psychiatryonline.org/content.aspx?bookid=28
&sectionid=1673332. Accessed February 24, 2014.

Attributed to A. John Rush, MD. Quick Inventory of Depressive Symptomatology (Self Report) (QID-SR16).

©2014 GSK group of companies.

All rights reserved. Printed in USA. 6065R0 April 2014
 Quick Inventory of Depressive Symptomatology
(16-item) (Self-Report) (QIDS-SR16)
Check the 1 response to each item that best describes you for the past 7 days.
1. Falling Asleep:
0 I never take longer than 30 minutes to fall
asleep.
1 I take at least 30 minutes to fall asleep, less
than half the time.
2 I take at least 30 minutes to fall asleep, more
than half the time.
3 I take more than 60 minutes to fall asleep,
more than half the time.
2. Sleep During the Night:
0 I do not wake up at night.
1 I have a restless, light sleep with a few brief
awakenings each night.
2 I wake up at least once a night, but I go back
to sleep easily.
3 I awaken more than once a night and stay
awake for 20 minutes or more, more than
half the time.
3. Waking Up Too Early:
0 Most of the time, I awaken no more than 30
minutes before I need to get up.
1 More than half the time, I awaken more than
30 minutes before I need to get up.
2 I almost always awaken at least 1 hour
or so before I need to, but I go back to
sleep eventually.
3 I awaken at least 1 hour before I need to,
and can’t go back to sleep.
4. Sleeping Too Much:
0 I sleep no longer than 7-8 hours/night,
without napping during the day.
1 I sleep no longer than 10 hours in a 24-hour
period including naps.
2 I sleep no longer than 12 hours in a 24-hour
period including naps.
3 I sleep longer than 12 hours in a 24-hour
period including naps.
5. Feeling Sad:
0 I do not feel sad.
1 I feel sad less than half the time.
2 I feel sad more than half the time.
3 I feel sad nearly all of the time.
Please complete either 6 or 7 (not both)
6. Decreased Appetite:
0 There is no change in my usual appetite.
1 I eat somewhat less often or lesser amounts
of food than usual.
2 I eat much less than usual and only with
personal effort.
3 I rarely eat within a 24-hour period, and
only with extreme personal effort or when
others persuade me to eat.
– OR –
7. Increased Appetite:
0 There is no change in my usual appetite.
1 I feel a need to eat more frequently than
usual.
2 I regularly eat more often and/or greater
amounts of food than usual.
3 I feel driven to overeat both at mealtime
and between meals.
Please complete either 8 or 9 (not both)
8. Decreased Weight
(Within the Last 2 Weeks):
0 I have not had a change in my weight.
1 I feel as if I’ve had a slight weight loss.
2 I have lost 2 pounds or more.
3 I have lost 5 pounds or more.
– OR –
9. Increased Weight
(Within the Last 2 Weeks):
0 I have not had a change in my weight.
1 I feel as if I’ve had a slight weight gain.
2 I have gained 2 pounds or more.
3 I have gained 5 pounds or more.
OVER
10. Concentration/Decision Making:
0 There is no change in my usual capacity to
concentrate or make decisions.
1 I occasionally feel indecisive or find that my
attention wanders.
2 Most of the time, I struggle to focus my
attention or to make decisions.
3 I cannot concentrate well enough to read or
cannot make even minor decisions.
11. View of Myself:
0 I see myself as equally worthwhile and
deserving as other people. 15. Feeling Slowed Down:
1 I am more self-blaming than usual.
2 I largely believe that I cause problems
for others.
3 I think almost constantly about major and
minor defects in myself.
12. Thoughts of Death or Suicide:
0 I do not think of suicide or death.
1 I feel that life is empty or wonder if it’s
worth living.
2 I think of suicide or death several times a 16. Feeling Restless:
week for several minutes.
3 I think of suicide or death several times a
day in some detail, or I have made specific
plans for suicide or have actually tried to
take my life.
13. General Interest:
0 There is no change from usual in how
interested I am in other people or activities.
1 I notice that I am less interested in people
or activities.
2 I find I have interest in only one or two of my
formerly pursued activities.
3 I have virtually no interest in formerly
pursued activities.
Attributed to A. John Rush, MD. Quick Inventory of Depressive Symptomatology (Self Report) (QID-SR16).
©2014 GSK group of companies.
All rights reserved. Printed in USA. 6065R0 April 2014
14. Energy Level:
0 There is no change in my usual level
of energy.
1 I get tired more easily than usual.
2 I have to make a big effort to start or
finish my usual daily activities (for example,
shopping, homework, cooking, or going
to work).
3 I really cannot carry out most of my usual
daily activities because I just don’t have
the energy.
0 I think, speak, and move at my usual rate
of speed.
1 I find that my thinking is slowed down or
my voice sounds dull or flat.
2 It takes me several seconds to respond to
most questions, and I’m sure my thinking
is slowed.
3 I am often unable to respond to questions
without extreme effort.
0 I do not feel restless.
1 I’m often fidgety, wringing my hands, or
need to shift how I am sitting.
2 I have impulses to move about and am
quite restless.
3 At times, I am unable to stay seated and
need to pace around.