DKI DKA

Akut Kronis
Etiologi Iritan kuat Iritan lemah Sensitisizer
Bahan iritan: Adanya kontak ulang
Alkali: sabun, detergen, amoniak, toilet cleansers, dengan allergen
plester
Asam: HCl, asam nitrat
Lai-lain: copper, merkuri, iodine, insektisida, gas,
debu
Patofisiologi Mediator keradangan (+) PA: limfosit
Ada 2 fase:
1. Fase induksi/sensitisasi
2. Fase elitisasi

PA: Leukosit
Iritan  penetrasi sawar Sawar kulit rusak 
kulit  sel membrane & epidermal turn over
lisozim rusak  radang meningkat, kulit
menebal, kering
Gejala Klinis Eritema, edema, bula, Kering, menebal, Eritema, batas kurang
epidermolysis, batas skuama, fisur, batas tegas
tegas tegas
Tes tempel: eritema tegas, saat diangkat berkurang Tes tempel: tak tegas, saat
diangkat tetap
Terapi Sistemik:
- Antihistamin
- Kortikosteroid
- Antibiotik
Topikal:
- Stadium Akut (basah): Kompres
- Stadium Subakut: Lotion, krim
- Stadium Kronis: Salep
Suportif: pendidikan, kesehatan, psikoterapi
Kortikosteroid Topikal

Inerson  Desoximethasone 0,25%

Nerilon  Diflucortolone valerate 0,1%  potent

Mometasone  Mometasone furoat  medium strength

Klobetasol  (Kloderma) Klobetasol propionate 0,05%  very potent

Hidrokortison  Hidrokortison

Desolex  Desonide 0,05%  mild strength

Efek samping:
ANTIHISTAMIN

Golongan Durasi
Generasi 1 Ethylenediamines
Kecil, molekul Ethanolamines
lipofilik yang Alkylamines
dapat Piperazines
menembus Tricyclics
BBB
Tidak spesifik
pada reseptor
H1
Generasi 2 Cetirizine
Lebih selektif Loratadine
untuk reseptor Terfenadine
perifer H1 Mizolastine
Astemizole

CTM  (Chlorfeniramin maleat)

Loratadine 

Cetirizine 

Efek samping:
Ruam Primer: macula, papul, plak, urtikaria, nodus, nodulus, vesikel, bula, pustule, dan kista

Ruam Sekunder: Skuama, krusta, erosi, ulkus, dan sikatrik

Tipe lesi, berbentuk, berukuran, susunan, distribusi, warna, konsistensi

The atopic march is a term that describes the progression of atopic disorders,
from eczema in young infants and toddlers to allergic rhinitis and finally to
asthma in older toddlers and children.1 Atopy is derived from a Greek word
meaning “strange or out of place” and was first introduced by Coca and Cooke
in 1923.2 Atopy is defined as a personal and/or familial tendency to produce
IgE antibodies and sensitization in response to ordinary exposures.3 Atopy is
associated with the development of eczema, rhinoconjunctivitis, and asthma,
all components of the atopic march.