ABSTRAK
Kata kunci : Kolagen, Sisik ikan nila, Barrier membrane, Regenerasi tulang
alveolar, Periodontitis
ABSTRACT
Background: Periodontitis is one of oral disease which results extensive alveolar bone
destruction even tooth loss so it will significantly impact on social aspects, function, and
esthetics. Incidence of periodontitis in Indonesia is quite high, reaching 60%. This high
incidence increasing demand for treatment. Lately, periodontitis treatment is not only
focused on eliminating periodontal pathogens but also, more oriented on regenerating
alveolar bone. Alveolar bone could be regenereated using Guided Tissue Regeneration
Method which rely on the function of collagen-based barrier membrane. Collagen plays
an important role in bone regeneration and biocompatible. Pure collagen is abundantly
contained in tilapia fish scales. Tilapia fish scale collagen can serve longer because it’s
high denaturation level. Purpose: To review tilapia fish scale collagen’s potential as an
alternative barrier membrane to regenerate alveolar bone in periodontitis cases.
Discussion: Successful GTR in bone regeneration relies on the exclusion of epithelium
and connective tissue, space maintenance, and fibrin clot induction. Regenerating bone
using membrane comprised of osteogenesis, osteoinduction, osteoconduction, and
angiogenesis. These stages are supported by collagen that is capable of preventing
epithelial cells invasion into bone defect area so angiogenesis process and osteogenic
cells migration run perfectly. Tilapia fish scale collagen, which are chemotactic for
epithelial cells and fibroblasts, stimulate and accelerate new bone tissue formation also
support osteoconduction proccess. As a hemostatic agent, Tilapia fish scale collagen
could strengthen fibrin attachment during bone maturation process. Conclusions:
Collagen in tilapia fish scale is potential as barrier membrane to regenerate alveolar bone
in periodontitis cases .
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