HEMATOPOIESIS
dr. Putu Ristyaning Ayu, M.Kes, Sp.PK
Bag Patologi Klinik_FK UNILA
I. Pendahuluan
2
A. Definisi
Hematopoiesis/ hemopoesis adalah proses pembentukan sel darah
produksi, diferensiasi, perkembangan serta pematangan dari semua
sel darah
pluripotent
6 stem cell
CFUGEMM Lymphoid
stem cell
Erythroid CFUEo
Progenitors CFUMeg CFUGM
CFUE
Thymus
CFU-M CFU-G
B T
Classification :
a. Non-lineage-specific GF act on pluripotential and
multipotential stem cells to initiate self-renewal and
differentiation
23
Name Source Function
IL - 1 Macrophages, T Stimulates growth of T and B cells,
and B cells, mediates inflammation, inhibits growth of
fibroblasts some cancer cells.
IL - 2 (T T cells Binds to receptors on cytotoxic T cells,
promote their growth, stimulates growth of
cells GF)
helper T cells.
IL - 4 T cells, NK cells, Stimulates & regulates growth and diff. of T
mast cells and B cells, eosinophils and basophils.
IL – 5 T cells Regulates production of eosinophils.
Activates mature eosinophils.
(Eo–GF)
IL - 6 Lymphocytes, Promotes macrophage formation.
fibroblasts Stimulates IgG production by B cells.
IL-7 Stromal Cells Supports long-term survival of B and T
cells in vitro.
IL - 8 Fibroblasts, Enhancement of neutrophil function
Hematologi Klinik Ringkas Prof.Dr. I Made Bakta
vasc. endot. Hematologi dan Transfusi Rukman Kiswari
Winstrobe’s Clinical Hematology
III. Limpa/Spleen
24
26
STEM CELLS
PRONORMOBLAST
BASOPHILIC NORMOBLAST
POLYCHROMATOPHILIC NORMOBLAST
ORTHOCHROMATOPHILIC NORMOBLAST
RETICULOCYTE
Types of leucocytes :
- Type of defense function : phagocytes (i.e., granu-
locytes and monocytes) and immunocytes (i.e.,
lymphocytes and plasma cells)
MYELOBLAST
PROMYELOCYTE
MYELOCYTE
METAMYELOCYTE
BAND FORM
Functions : ~ Chemotaxis
~ Cytotoxic activities : phagocytosis
and granule toxicity
Life span and circulation :
~ Transit time in blood for mature neutrophils :
1 day or less.
~ Probably survive 1-2 days in tissue.
~ N peripheral blood levels : 4.0 – 10 x 103/ul
Functions :
~ a first line defense against parasites
~ modulate hypersensitivity reactions
~ migrate to inflammatory sites
Life span and circulation :
~ Usually exist in concentr. of 100-400/ul in PB
~ BM maturation time : 2-6 days , circ. half life : 6 - 12 hours
Functions : ~
involved in immediately hypersensitivity
~ trigger anaphylactic degranulation
~ active arachidonic acid metabolites
(e.g..leukotrienes, prostaglandin)
Life span and circulation :
~ Basophils : about 1-2 days
~ Mast cells : present in blood only in pathologic
conditions. Mast cells survive several weeks to
several month in tissue
Functions : Morphology :
~ Activating stimuli Monoblast
~ Chemotaxis
~ Phagocytosis Promonocytes
Monocytes
Life span :
4.5 – 10 hours (mean 8.5 h)
Mature T cell
Function
CSF-Mega
Thrombopoietin (TP)